FC Cincinnati is heavily favored to win the second leg on February 26, 2026, after their dominant 4-0 victory in the first leg against Universidad O&M on February 18, with odds around -150 moneyline reflecting their strong form and away dominance in recent MLS matches. Key players like their top scorer with 5 goals in the last 4 games bolster their attack at TQL Stadium. Bet on DexWin - Best Odds on Your Favourite Sports.

The match starts at 12:00 AM UTC on February 26, 2026, which is 7:00 PM ET on February 25, 2026, at TQL Stadium in Cincinnati, Ohio.

TQL Stadium in Cincinnati, Ohio, USA, hosts the game with a capacity of 26,000 seats, featuring a modern design and vibrant atmosphere for FC Cincinnati's home CONCACAF Champions Cup matches.

FC Cincinnati is predicted to win 3-0 or better, advancing easily with moneyline odds of -150 and spread at -1.5, given their recent 4-0 first-leg rout and Universidad O&M's poor defensive record conceding 12 goals in their last 5 games on DexWin.

In their first meeting on February 18, 2026, FC Cincinnati crushed Universidad O&M 4-0; no prior head-to-head exists, but Cincinnati's recent form shows 7 wins in 10 matches while O&M struggles with just 2 wins in their last 8.