England are favored to win against Italy with odds around 1.80, as they remain the only Six Nations team never to have lost to Italy historically. However, Italy's defensive resolve has been impressive this season, conceding just 15 second-half points against Ireland and eight against Scotland, making them a tougher opponent than their ranking suggests with DexWin - Best Odds on Your Favourite Sports.

The match starts at 4:40 PM UTC on March 7, 2026, which corresponds to 5:40 PM CET (Central European Time) in Italy.

The match will be played at the Stadio Olimpico in Rome, Italy, one of the Six Nations' iconic venues with a capacity of approximately 70,634 seats.

England are predicted to win with moneyline odds of 1.80, though Italy's recent defensive improvements suggest the match could be closer than expected. Italy has shown they can keep scores down, with both their games this season producing just 33 total points, making an under 58.5 total points bet worth considering at 1.90 odds.

England remain undefeated against Italy in Six Nations history, holding a perfect record in their head-to-head matchups. This historical dominance, combined with England's recent form despite recent losses to Scotland and Ireland, positions them as clear favorites despite Italy's improved defensive organization this season.