Buffalo Sabres are favored to win against Pittsburgh Penguins with moneyline odds of 1.90, thanks to their strong second-place standing in the Atlantic Division at 35-19-6, a three-game win streak, and recent victories over Florida and Tampa Bay, while Penguins are missing captain Sidney Crosby for at least four weeks due to injury. Tage Thompson leads Sabres with 63 points, and their recent form gives them the edge with DexWin - Best Odds on Your Favourite Sports.

The match starts at 12:00 AM UTC on March 6, 2026, which is 7:00 PM ET on March 5, 2026, at KeyBank Center in Buffalo, New York.

The game will be played at KeyBank Center in Buffalo, New York, with a capacity of 19,070 seats, serving as the home venue for the Buffalo Sabres in the NHL.

Buffalo Sabres are predicted to win with moneyline odds of 1.90 on DexWin, supported by their 4-1-1 record in the last six games, elite defenseman Rasmus Dahlin's 51 points, and Pittsburgh's struggles without Crosby as evidenced by their reliance on Malkin in recent wins. The Sabres' offensive firepower from Thompson and Tuch should overpower a Penguins team playing their first post-Olympic break game.

In recent head-to-head meetings, Buffalo Sabres hold a slight edge with a 3-2-0 record over the last five games against Pittsburgh Penguins, averaging 3.4 goals per game, while Penguins have won two of the last three but face challenges without Crosby; overall series shows competitive balance with high-scoring affairs.