Houston Dynamo FC are favored to win this MLS match with moneyline odds around 1.90, while Chicago Fire FC are positioned as underdogs at 2.05. Houston's home advantage at BBVA Stadium and their strong recent form in early season play give them the edge over a Fire side that will be traveling after their season opener on February 21 against Houston, with DexWin - Best Odds on Your Favourite Sports.

The match kicks off at 1:30 AM UTC on February 22, 2026, which corresponds to 8:30 PM CST on February 21, 2026 in Houston, Texas. This timing reflects the early MLS season schedule with matches played in the evening local time.

The match will be played at BBVA Stadium in Houston, Texas, the home of Houston Dynamo FC. The stadium has a seating capacity of 22,039 and is located in the heart of Houston's sports district.

Houston Dynamo FC are predicted to secure a victory with odds of 1.90 on the moneyline. The Dynamo have the advantage of playing at home in their season opener, and Chicago Fire will be traveling after their own debut match just 24 hours earlier, which could impact their performance and fatigue levels.

The head-to-head record between Houston Dynamo FC and Chicago Fire FC shows a competitive rivalry in MLS play. Historically, these teams have split results relatively evenly, with recent seasons showing Houston maintaining a slight edge in home matches. The Fire's travel schedule and quick turnaround from their February 21 opener puts them at a disadvantage in this fixture.