AFC Ajax is favored to win with Asian handicap odds of -1.5 at -112, indicating strong confidence in their victory. Ajax's home advantage at Johan Cruijff Arena and their status as one of the Eredivisie's top teams make them the clear betting favorites over Excelsior Rotterdam.

The match starts at 5:45 PM UTC on November 22, 2025, which corresponds to 6:45 PM CET (Central European Time) for local Amsterdam time.

The match will be played at Johan Cruijff Arena in Amsterdam, Netherlands. This is Ajax's home stadium and one of the premier football venues in Europe, located in the capital city.

Ajax are predicted to win with 3-way handicap odds showing Ajax at -1 with -120 odds, while Excelsior Rotterdam at +1 carries 225 odds. The Asian handicap of -1.5 for Ajax at -112 suggests a comfortable home victory is expected, with bookmakers across multiple platforms heavily favoring the Amsterdam club.

Specific head-to-head statistics between Ajax and Excelsior Rotterdam for recent seasons are not available in the current data. However, Ajax's superior league position and home record typically give them a significant advantage in direct matchups against lower-ranked Eredivisie opponents like Excelsior Rotterdam.