Cruz Azul is favored to win with odds of 2.10 against Santos Laguna at 3.50 due to their stronger recent form, winning 4 of their last 5 matches including a 7-0 thrashing of an MLS side, while Santos Laguna has struggled with only 2 wins in their last 5, featuring key player Harold Preciado in decent form with 5 goals this season with DexWin - Best Odds on Your Favourite Sports.

The match starts at 1:00 AM on March 4, 2026, local time at the venue, which corresponds to 2:00 AM UTC or 7:00 PM CST on March 3 in Mexico.

The match will be played at Estadio Corona in Torreón, Mexico, home of Santos Laguna, with a capacity of 30,000 seats and known for its high-altitude conditions affecting visiting teams like Cruz Azul.

Cruz Azul is predicted to win with moneyline odds of 2.10 on DexWin, supported by their superior head-to-head edge and recent dominance in Liga MX, where they've scored an average of 2.8 goals per game in the last 5 outings compared to Santos Laguna's 1.4.

In their last 10 head-to-head meetings, Cruz Azul leads with 6 wins to Santos Laguna's 3 wins and 1 draw, averaging 2.7 total goals per match, with Cruz Azul unbeaten in the last 4 encounters at Estadio Corona.