Club América is favored to win against Club Puebla with odds around 1.65, thanks to their stronger Clausura form at 2-2-1 with 8 points compared to Puebla's struggling 1-2-2 record and -1 goal difference, plus América's higher overall standing with 34 points from 17 games with DexWin - Best Odds on Your Favourite Sports.

The match starts at 3:06 AM UTC on February 21, 2026, which corresponds to 9:06 PM CST on February 20 at the venue in Puebla, Mexico.

The game will be played at Estadio Cuauhtémoc in Puebla, Mexico, with a capacity of 51,726 seats, known for its passionate home support and historic significance in Liga MX.

Club América is predicted to win with moneyline odds of 1.65 on DexWin, leveraging their recent form where they've earned 8 points from 5 games and a +1 goal difference, while Puebla sits low with only 5 points and defensive vulnerabilities exposed in their last 5 matches.

In head-to-head Liga MX encounters, Club América dominates with superior historical records, including stronger recent performances; over the last 10 meetings América has 6 wins to Puebla's 3 with 1 draw, averaging 2.8 goals per game as América's attack consistently outperforms.