Club América are favored to win, with most recent Liga MX outright and match markets pricing them around 1.45–1.55 to win in 90 minutes, Atletico San Luis near 5.50–6.50, and the draw around 4.00 thanks to América’s deeper squad and stronger league performance in the 2025–26 Apertura. DexWin - Best Odds on Your Favourite Sports.

The Club América vs Atletico San Luis Liga MX match is scheduled to start on 15 January 2026 at 1:00 AM UTC, which corresponds to 7:00 PM local time on 14 January 2026 in Mexico City and San Luis Potosí (CST, UTC-6).

As a Liga MX Clausura 2026 fixture, this game is set to be played at Estadio Alfonso Lastras in San Luis Potosí, Mexico, Atletico San Luis’s home ground, with an all-seater capacity of approximately 27,000 fans and a traditional grass surface that tends to favor high-tempo attacking play.

Based on recent form where Club América have consistently finished in the top spots and often lead the league in goals scored, while Atletico San Luis have hovered around mid-to-lower table, the prediction leans toward an América win with a handicap line of América -0.75 at about 1.80–1.95 and over 2.5 goals trading close to 1.80, indicating bookmakers expect América to control the match but still price in some home resistance.

In recent head-to-head Liga MX meetings over the past few seasons, Club América have dominated Atletico San Luis with América winning the majority of matches, San Luis taking only a small handful of victories, and draws being relatively rare, with an average combined goals figure typically above 2.5 per game, underscoring América’s attacking edge in this matchup.