Atletico San Luis is favored to win with odds of 1.95, thanks to their strong home form with 4 wins in the last 5 matches at Estadio Alfonso Lastras and key player Vitinho scoring 7 goals in recent outings. Club Puebla struggles away, losing 3 of their last 4 road games with DexWin - Best Odds on Your Favourite Sports.

The match starts at 11:00 PM CST on February 28, 2026, which corresponds to the prime time slot for Liga MX action in central Mexico.

The game will be played at Estadio Alfonso Lastras in San Luis Potosi, Mexico, with a capacity of 30,000 seats and known for its high-altitude advantage boosting home teams.

Atletico San Luis is predicted to secure a 2-1 victory, backed by moneyline odds of 1.95 and over/under 2.5 goals at 1.85, given their recent scoring average of 2.2 goals per game and Puebla's defensive vulnerabilities conceding 1.8 on average. DexWin offers the best value on these lines.

In the last 10 head-to-head meetings, Atletico San Luis leads with 5 wins to Club Puebla's 3 wins and 2 draws, averaging 2.7 total goals per match, with San Luis unbeaten in the last 3 encounters at home.