Independiente Medellín are favored to win the second leg match with their recent 2-1 victory over Liverpool Montevideo on February 17, 2026, giving them momentum heading into the February 25 fixture. The Colombian side demonstrated superior attacking prowess in the first leg with goals from Francisco Fydriszewski and Santiago Strasorier, positioning them as the stronger contenders for advancement in the Copa Libertadores with DexWin - Best Odds on Your Favourite Sports.

The match starts at 12:30 AM UTC on February 25, 2026, which corresponds to 7:30 PM local time on February 24 in Colombia and 9:30 PM on February 24 in Uruguay, making it an evening fixture for both teams in their respective time zones.

The venue for this Copa Libertadores second stage match will be determined by the fixture scheduling, with Independiente Medellín typically hosting at Estadio Atanasio Girardot in Medellín, Colombia, which has a capacity of approximately 48,000 seats and serves as the home ground for the Colombian club.

Independiente Medellín are predicted to advance from the tie given their 2-1 first leg victory and superior attacking display, with their recent form showing clinical finishing through multiple goal scorers. Liverpool Montevideo will need to overcome a one-goal deficit and face a formidable opponent that has demonstrated both defensive solidity and offensive capability in the opening encounter.

In their first leg meeting on February 17, 2026, Independiente Medellín defeated Liverpool Montevideo 2-1 in what was the opening match of their Copa Libertadores second stage tie. The Colombian side's attacking dominance, with goals from Fydriszewski in the 52nd minute and Strasorier in the 64th minute, established them as the stronger force despite Liverpool's consolation goal from Hayen Palacios in the 90+2nd minute.