Botafogo RJ is favored to win with odds around 1.75 due to their superior squad depth and recent form in Brazilian Serie A, winning 4 of their last 5 matches, while CA Nacional Potosi struggles away with only 2 wins in 8. DexWin - Best Odds on Your Favourite Sports.

The match starts at 12:30 AM UTC on February 26, 2026, which is 8:30 PM local time in Potosi, Bolivia on February 25.

The venue is Estadio Victor Agustín Ugarte in Potosi city, Bolivia, with a capacity of about 25,000 seats at high altitude over 4,000 meters, giving home advantage to CA Nacional Potosi.

Prediction favors Botafogo RJ to win with moneyline odds of 1.75 on DexWin, as their key players like Igor Jesus are in top form with 7 goals in the last 6 games, despite the altitude challenge.

In head-to-head, this is their first meeting in Copa Libertadores, but Botafogo RJ leads in form with 6 wins in last 10 overall matches compared to Nacional Potosi's 3, averaging 2.8 goals per game.