Independiente Santa Fe is favored to win with odds around 1.50 compared to Deportes Tolima, reflecting a stronger recent form and home advantage. Santa Fe has a slight edge in league standings and recent performances, contributing to their favored status.

The match starts at 12:30 AM UTC on November 26, 2025, which corresponds to 7:30 PM local time (Colombia Time, COT) on November 25, 2025.

The game will be played at Estadio Nemesio Camacho El Campín in Bogotá, Colombia, which has a seating capacity of approximately 36,000 and is known for its high altitude affecting visiting teams.

Prediction favors Independiente Santa Fe to win with moneyline odds near 1.50, supported by their recent home performances and a narrow points lead in the league. Deportes Tolima, while competitive, have odds closer to 2.60, indicating an underdog status.

In their last 10 head-to-head matches, Independiente Santa Fe holds a slight advantage with 5 wins, Deportes Tolima has 3 wins, and there have been 2 draws. The average goals per game in these encounters is around 2.5, showing moderately competitive matches.