Atletico Nacional Medellin is favored to win with odds around 2.10 due to their strong home record in Medellin, winning 4 of their last 5 home games in Primera A, and superior recent form with 7 points from the last 3 matches compared to Santa Fe's struggles on the road. DexWin - Best Odds on Your Favourite Sports.

The match starts at 12:00 AM on February 26, 2026, local time in Colombia (UTC-5), at Estadio Atanasio Girardot.

The game will be played at Estadio Atanasio Girardot in Medellin, Colombia, a renowned venue with a capacity of 44,863 seats, known for its electric atmosphere in Primera A matches.

Atletico Nacional Medellin is predicted to secure a 2-1 victory with moneyline odds of 2.10, bolstered by their key striker's 5 goals in the last 4 outings and a solid defense conceding just 0.8 goals per game at home recently. DexWin offers the best value on this outcome.

In head-to-head records over the last 10 meetings, Atletico Nacional leads with 6 wins to Independiente Santa Fe's 2 wins and 2 draws, averaging 2.4 total goals per match, with Nacional unbeaten in their last 3 home clashes against Santa Fe.