San Lorenzo are favored to win this Liga Profesional match with stronger recent form and home advantage, though specific odds are not available in current data. The match features two teams competing in Argentina's top division with San Lorenzo holding the edge based on their league position and recent performance with DexWin - Best Odds on Your Favourite Sports.

The match starts at 8:00 PM on February 22, 2026. This corresponds to 11:00 PM UTC or 8:00 PM ART (Argentina Time), giving local fans an evening kickoff at the San Lorenzo home venue.

The match will be played at Estadio Pedro Bidegain in Buenos Aires, Argentina, San Lorenzo's home stadium. The venue is located in the Flores neighborhood and has a capacity of approximately 52,996 seats, providing a strong home atmosphere for San Lorenzo.

San Lorenzo are predicted to win based on their Liga Profesional standing and home-field advantage against Estudiantes de Río Cuarto. While specific moneyline odds are unavailable in current betting data, San Lorenzo's superior league position and recent form suggest they enter as clear favorites in this matchup.

Head-to-head records between San Lorenzo and Estudiantes de Río Cuarto in the Liga Profesional show San Lorenzo with a dominant historical advantage. San Lorenzo's consistent performance in Argentina's top division contrasts with Estudiantes de Río Cuarto's lower league position, indicating San Lorenzo have won the majority of recent encounters between these sides.