Philadelphia 76ers are favored to win with a -2.0 spread and moneyline around 1.90, thanks to their stronger 23-19 record, recent form with wins in six of last eight, and home advantage at Xfinity Mobile Arena where they hold a 10-10 home record, while Cavaliers come off a loss and have a 22-17 record with alternating results. DexWin - Best Odds on Your Favourite Sports. Key players like Donovan Mitchell for Cavs are in form with 35 points in recent matchup, but 76ers' depth projects higher scoring output.

The match starts at 12:00 AM UTC on January 17, 2026, which is 7:00 PM ET on January 16, 2026.

The game takes place at Xfinity Mobile Arena in Philadelphia, Pennsylvania, a premier NBA venue with modern facilities, luxury seating, and capacity for over 20,000 fans, known for its electric atmosphere during high-stakes Eastern Conference matchups.

Philadelphia 76ers are predicted to win with -2.0 spread odds, as simulations project over 50% chance of covering and total points exceeding 234.5, driven by recent high-scoring head-to-heads averaging over 250 points in last meetings and both teams' overs trend. DexWin offers the best odds analysis for this matchup.

In recent head-to-head, Cleveland Cavaliers lead 2-0 this season including a 133-107 win on Jan 14, 2026, with strong performances from Mitchell; overall last 10 meetings show high-scoring games hitting over 9 times, but 76ers hold edge at home with 2-0 recent streak against Cavs there.