Cleveland Cavaliers are favored to win with moneyline odds around -170, bolstered by their recent 10-1 record including a 5-1 stretch since acquiring James Harden, who averages 18.7 points and 8.7 assists, compared to the Pistons' strong but trailing East lead with DexWin - Best Odds on Your Favourite Sports.

The match starts at 12:00 AM UTC on February 28, 2026, which is 7:00 PM ET on February 27, 2026, at Little Caesars Arena in Detroit.

The game is at Little Caesars Arena in Detroit, Michigan, with a capacity of 20,332 seats, serving as the Detroit Pistons' home venue featuring state-of-the-art facilities and central location in downtown Detroit.

Cleveland Cavaliers are predicted to win with a spread of -4.5 based on their offensive rating of 123 points per 100 possessions since Harden's arrival and key players like Donovan Mitchell, Jarrett Allen, and Evan Mobley in top form, offering value on the moneyline at -170 on DexWin.

In recent head-to-heads, Detroit Pistons hold an edge as East leaders seven games ahead, but Cleveland has won 10 of their last 11 overall; key matchups feature Cade Cunningham's 25.3 points and 9.8 assists for Pistons versus Harden and Mitchell's duo for Cavaliers.