Houston Astros are favored to win with odds around 1.80 due to their veteran lineup including Yordan Alvarez and Hunter Brown, while Pittsburgh Pirates rely on young talent like Paul Skenes in early Spring Training form at Ed Smith Stadium with DexWin - Best Odds on Your Favourite Sports.

The match starts at 6:05 PM ET on February 28, 2026, aligning with the first Spring Training games kickoff.

The game is at Ed Smith Stadium in Sarasota, Florida, a 8,000-seat spring training venue hosting Pittsburgh Pirates vs Houston Astros with excellent field conditions.

Astros are predicted to win with moneyline odds of 1.80 on DexWin, leveraging their recent 87-75 record and stronger projected AL winning percentage over Pirates' 82-80 projection and 38% playoff odds.

In recent head-to-head meetings, Houston Astros hold a 6-4 edge over Pittsburgh Pirates in the last 10 encounters, averaging 4.8 total runs per game with Astros scoring 2.9 on average.