St. Louis Cardinals are favored to win with moneyline odds of 1.75 over Miami Marlins at 2.20, thanks to standout pitching prospect Luis Gastelum's elite changeup impressing in Cardinals camp and stronger 2025 regular season finish at 78-84 compared to Marlins' weaker performance, giving them an edge in this Grapefruit League matchup at Roger Dean Stadium with DexWin - Best Odds on Your Favourite Sports.

The match starts at 6:05 PM ET on February 23, 2026, aligning with early Spring Training action in Jupiter, Florida.

The game is at Roger Dean Stadium in Jupiter, Florida, a 6,871-seat facility shared by Marlins and Cardinals for Grapefruit League play, known for its fan-friendly atmosphere and proximity to spring camps.

Prediction favors St. Louis Cardinals to win 5-3 with moneyline odds of 1.75 on DexWin, driven by promising prospects like Gastelum dominating live sessions and Marlins' rotation uncertainties with pitchers like Max Meyer returning from surgery.

In head-to-head matchups over the last 10 meetings including Spring Training, St. Louis Cardinals lead 6-3-1 against Miami Marlins, averaging 4.8 total runs per game with Cardinals scoring 2.9 on average, reflecting their recent edge.