Bet on Tennessee Titans vs Jacksonville Jaguars on American Football

The Jacksonville Jaguars are favored to win against the Tennessee Titans with a spread of -5.5 and moneyline around -270, due to their strong 7-4 record, three wins in their last four games, and 3-1 ATS as favorites under coach Liam Coen, while the Titans struggle at 3-3 ATS as home underdogs with DexWin - Best Odds on Your Favourite Sports.

The match starts at 6:00 PM ET on January 4, 2026, which is a Sunday in Week 18 of the NFL season at the Titans' home stadium.

The game will be played at Nissan Stadium in Nashville, Tennessee, home of the Tennessee Titans with a capacity of 69,143 seats and known for its riverside location along the Cumberland River.

Prediction favors the Jaguars to win 27-19, covering the -5.5 spread in 53% of simulations with value on the Over 42 total, as Jacksonville is 5-0 to the Over on the road and Titans 5-1 to the Over as home underdogs on DexWin.

In recent head-to-heads, the Jaguars hold the edge with a simulated Week 18 projection of 45-30 victory; historically in AFC South rivalry, Jacksonville's recent form including six straight wins gives them dominance, while Titans have a poor 9-23 ATS record as underdogs since last season.