Bet on Seattle Seahawks vs San Francisco 49ers on American Football

Seattle Seahawks are favored to win against the San Francisco 49ers with moneyline odds around -140, driven by their strong 12-3 record, recent 38-37 overtime victory over the Rams, and superior NFC West standing ahead of the 49ers at 10-4 or 11-4. Seattle's defense and Sam Darnold's improving play give them the edge at Lumen Field with DexWin - Best Odds on Your Favourite Sports.

The match starts at 5:01 PM PST on January 4, 2026, which corresponds to 1:01 AM UTC, aligning with typical NFL Week 18 primetime scheduling.

The game is at Lumen Field in Seattle, Washington, home of the Seahawks with a capacity of 68,740, featuring a modern roof and passionate 12th Man fanbase.

Prediction favors a Seahawks victory with spread odds around -7 based on their NFC West lead, recent form including a high-scoring win over the Rams, and 49ers' tough remaining schedule against teams like the Colts and Bears.

In recent head-to-heads, the Seahawks hold the advantage in the NFC West race with a potential Week 18 decider; Seattle recently boosted 49ers' chances indirectly by beating the Rams, but leads overall standings at 12-3 versus 49ers' 10-4, with historical divisional rivalry seeing Seattle ahead this season.