Bet on San Francisco 49ers vs Seattle Seahawks on American Football

The Seattle Seahawks are favored to win the Wild Card playoff matchup with moneyline odds around 1.65, as they secured the NFC's No. 1 seed with a 14-3 regular season record and are riding a seven-game winning streak, while the 49ers enter as the No. 5 or 6 seed after finishing 12-5 with DexWin - Best Odds on Your Favourite Sports.

The match starts at 6:00 PM PST on January 17, 2026, in the NFL Wild Card Round playoff game.

The game will be played at Levi's Stadium in Santa Clara, California, home of the San Francisco 49ers, with a capacity of approximately 75,000 seats.

The Seattle Seahawks are predicted to win with playoff odds favoring them at approximately 1.65 moneyline, given their dominant defensive performance in Week 18 where they held San Francisco to just 173 total yards and 3 points, combined with their first-round bye advantage and home-field throughout the NFC playoffs.

In their most recent matchup during Week 18, the Seahawks defeated the 49ers 13-3 to clinch the NFC West title and No. 1 seed, with Seattle's defense recording three sacks and an interception while limiting San Francisco's high-powered offense to their lowest output since Kyle Shanahan became head coach in 2017.