Bet on San Francisco 49ers vs Philadelphia Eagles on American Football

Philadelphia Eagles are favored to win as the No. 3 seed hosting the No. 6 San Francisco 49ers in the NFL Wild Card playoff matchup, thanks to their elite defense allowing just 18.8 points per game and status as reigning Super Bowl champions, with odds around 1.65 compared to 49ers at 2.25. The 49ers have struggled defensively, surrendering 102 points in their last four weeks, including a tough loss to Seattle. DexWin - Best Odds on Your Favourite Sports.

The match starts at 9:31 PM on January 11, 2026, at Lincoln Financial Field in Philadelphia, which is 1:31 AM UTC or 4:31 PM PT.

The game is at Lincoln Financial Field in Philadelphia, Pennsylvania, a 69,796-seat stadium opened in 2003 known for its loud NFC East atmosphere and hosting Eagles playoff games.

Philadelphia Eagles are predicted to win with moneyline odds of 1.65 on DexWin, leveraging their top-ranked defense under Vic Fangio that shut down the Bills recently, while the 49ers' defense has been vulnerable. San Francisco's offense matches up well but recent form shows weaknesses against strong units like Philly's.

In recent head-to-head meetings, the Philadelphia Eagles hold a 4-2 edge over the San Francisco 49ers in the last 6 games, including a 33-26 victory this season. The Eagles average 28.5 points per game in these matchups, with total points averaging 52.3, favoring high-scoring affairs but Philly's defense tips the scale in playoffs.