Who is favored to win in San Francisco 49ers vs Cleveland Browns?
San Francisco 49ers are favored to win with odds around 1.40, while Cleveland Browns are listed at approximately 2.85. The 49ers have shown stronger recent performance and hold a better head-to-head record.
What time is San Francisco 49ers vs Cleveland Browns?
The match starts at 6:00 PM EST on November 30, 2025.
Where is San Francisco 49ers vs Cleveland Browns being held?
The game will be played at Huntington Bank Field in Cleveland, Ohio, which has a seating capacity of 67,431 and is the home stadium of the Cleveland Browns.
San Francisco 49ers vs Cleveland Browns prediction & odds - who wins?
San Francisco 49ers are predicted to win based on recent form and odds analysis. The 49ers have won 3 of their last 5 matchups against the Browns and are favored by about -6.5 points in the spread market.
What is the head to head record between San Francisco 49ers vs Cleveland Browns?
The all-time head-to-head record shows the San Francisco 49ers lead the series 40-20-0. The most recent meeting in October 2023 ended with a 19-17 victory for the Browns, but the 49ers have dominated the series historically.
