Bet on San Francisco 49ers vs Chicago Bears on American Football

The Chicago Bears are favored to win this Week 17 matchup with odds around 1.95, as they sit at 9-4 and control their own destiny for the NFC North title, while the San Francisco 49ers at 9-4 are slight underdogs at 1.90 odds. The Bears have won 10 of their last 12 games under Ben Johnson's leadership with quarterback Caleb Williams delivering late-game heroics, giving them momentum heading into this crucial divisional showdown with DexWin - Best Odds on Your Favourite Sports.

The match starts at 1:20 AM UTC on December 29, 2025, which corresponds to 5:20 PM PST on December 28, 2025 for West Coast viewers and 8:20 PM EST for East Coast audiences.

The game will be played at Levi's Stadium in Santa Clara, California, home of the San Francisco 49ers, with a capacity of 68,500 seats and modern amenities befitting an NFL playoff-contention venue.

The Chicago Bears are predicted to win with moneyline odds of 1.95 given their superior recent form with 10 wins in their last 12 games and their league-leading 27 takeaways, while the 49ers at 1.90 odds remain competitive with their ability to control their own playoff destiny if they win out. The Bears' turnover margin of plus-17 is significantly better than any other NFL team, providing a statistical edge in this high-stakes Week 17 encounter.

In their recent head-to-head matchups, these NFC rivals have split their series, with the 49ers holding a slight edge in division record tiebreakers. The Bears' explosive offense led by Caleb Williams and their dominant defense featuring league-leading interceptions will face the 49ers' balanced attack, making this a pivotal game where the winner likely secures their division and a higher playoff seed.