Buffalo Bills are favored to win the NFL matchup against Philadelphia Eagles on December 28, 2025, with moneyline odds around 1.75 due to their stronger 10-4 record, Josh Allen's elite play, and home advantage at Highmark Stadium, while the Eagles sit at 9-5 after recent inconsistencies with DexWin - Best Odds on Your Favourite Sports.

The Philadelphia Eagles vs. Buffalo Bills game starts at 9:25 PM ET on December 28, 2025, which is 2:25 AM UTC on December 29.

The match takes place at Highmark Stadium in Orchard Park, New York, home of the Buffalo Bills with a capacity of 71,608 seats and known for its cold-weather conditions in late December.

Prediction favors the Buffalo Bills to win with odds of 1.75 on the moneyline, leveraging their recent surge including a comeback against the Bengals and a 10-4 record, while Eagles' defense has struggled lately despite clinching the NFC East.

In recent head-to-head meetings, Buffalo Bills hold a 4-2 edge over Philadelphia Eagles in the last 6 games, with an average total score of 48 points; the Bills won their most recent clash 35-7 in simulations reflecting strong form.