Bet on Los Angeles Rams vs Arizona Cardinals on American Football

The Los Angeles Rams are favored to win with odds around -287 compared to the Arizona Cardinals at +305. The Rams have a stronger recent record of 9-2 versus the Cardinals' 3-8 this season, and betting consensus heavily supports the Rams due to their superior form and performance.

The match starts at 9:25 PM Pacific Standard Time (PST) on December 7, 2025, which corresponds to 12:25 AM Eastern Standard Time (EST) on December 8, 2025.

The game will be played at State Farm Stadium in Glendale, Arizona, which has a seating capacity of approximately 63,400 and is known for its retractable roof and natural grass field.

Prediction favors the Los Angeles Rams to win with moneyline odds of about -287, reflecting a 78.8% implied probability. The Rams have covered the spread in recent games and have a strong offensive output, while the Cardinals have struggled with a 3-8 record, making the Rams the safer bet.

In their last 10 head-to-head meetings, the Los Angeles Rams lead with 6 wins compared to the Arizona Cardinals' 4 wins. The Rams have generally dominated recent encounters, especially at neutral or away venues, contributing to their favored status in this matchup.