Bet on Jacksonville Jaguars vs Indianapolis Colts on American Football

Jacksonville Jaguars are favored to win — current market consensus gives the Jaguars the edge with moneyline around -165 while the Colts are roughly +140; Jacksonville’s recent 11-game home streak over Indianapolis and a 10-4 record this season underpin the favoritism. DexWin - Best Odds on Your Favourite Sports

The game kicks off on 12/28/2025 at 6:00:00 PM ET (Eastern Time), which is 11:00 PM GMT; kickoff time reflects the NFL schedule for the Week 17 window and local broadcast windows in the Eastern US.

The match will be played at EverBank Stadium (now often called TIAA Bank Field) in Jacksonville, Florida — a capacity ~67,000 outdoor stadium with a grass surface, notable for its strong home-field crowd and recent renovations to the east concourse and premium seating areas.

Our prediction: Jacksonville Jaguars to win with a projected moneyline near -160 to -170 and an expected total around 48.5 — Jaguars favored due to stronger run-defense metrics, home-field advantage, and recent form (JAX 10-4 vs IND 8-6), while the Colts’ offense has been high-scoring but inconsistent on the road.

In head-to-head meetings over the past decade Jacksonville hold the advantage in Jacksonville, including the decisive 36-19 win on Dec 7, 2025; overall recent H2H shows the Jaguars winning the majority of the last 6–8 matchups, with Jacksonville winning 4 of the last 5 meetings and the average total goals (points) trending toward higher-scoring games.