Denver Broncos are favored to win — market consensus gives Denver a clear edge coming in as the AFC’s top seed with implied moneyline around -160 to -180 while Jacksonville sits near +140 to +160 due to Denver’s superior 11–2 form and home-field advantage at Mile High (odds fluctuate, check live markets for the latest).

The game kicks off on 2025-12-21 at 9:05:00 PM Eastern Time (ET), which is 7:05:00 PM Mountain Time (MT) in Denver and 2:05:00 AM UTC on 2025-12-22 for international viewers.

The match is at Empower Field at Mile High in Denver, Colorado — a high-altitude stadium (~5,280 ft elevation) known for loud crowds, a turf surface and capacity near 76,000, which benefits Denver’s passing game and teams used to thinner air and stronger home-field conditions.

Prediction: Denver to win (moneyline ≈ -170) with a cautious spread play of Broncos -3; the odds favor Denver because they are 11–2 with an ongoing dominant stretch while Jacksonville (around 10–4) has recent form but faces the altitude and Denver’s top-ranked defense, making Denver the smarter wager for both moneyline and small spread — consider hedging with an over/under bet if key weather or injury news changes the line. DexWin - Best Odds on Your Favourite Sports.

In head-to-head history across recent seasons the Broncos hold the advantage in meetings, winning the majority of their matchups including the most consequential late-season games; their last meeting earlier this season showed Denver’s consistency while Jacksonville has been competitive but trails in wins and average margin in these fixtures.