The Arizona Cardinals are favored to win with a spread of -1.5 and moneyline odds of -125, giving them approximately a 53.3% chance of victory. The Cardinals' favorable odds reflect their home-field advantage at State Farm Stadium, though they enter the matchup with a 3-6 record compared to Jacksonville's 5-4 record.

The match starts at 9:05 PM EST on November 23, 2025. This is an evening kickoff on Sunday, providing prime-time viewing for NFL fans across the eastern time zone.

The game will be played at State Farm Stadium located in Glendale, Arizona. This is the Arizona Cardinals' home venue where they have shown strength against the spread with a 4-1 record in road games this season.

The Arizona Cardinals are predicted to win based on the current betting odds of -1.5 spread and -125 moneyline. The Cardinals' recent form shows they are 3-2 against the spread in their last 5 games, and their home-field advantage combined with Jacksonville's inconsistent performance makes them the statistical favorite despite their lower overall win-loss record.

Head-to-head historical records between these franchises are not provided in the available data. However, the matchup features Jacksonville entering as the higher-seeded team with a 5-4 record while Arizona sits at 3-6, indicating Jacksonville has performed better this season despite being underdogs in this particular contest.