Bet on Indianapolis Colts vs Jacksonville Jaguars on American Football

Jacksonville Jaguars are favored to win with moneyline odds of +127 against the Indianapolis Colts who are at -170. The Jaguars have a strong recent form with 4 wins in their last 5 games, while the Colts have a mixed record, making the Jaguars slight favorites despite the Colts being favored by point spread in some markets.

The match starts at 1:00 PM Eastern Standard Time (EST) on December 7, 2025.

The game will be played at EverBank Stadium in Jacksonville, Florida, which is the home stadium of the Jacksonville Jaguars with a seating capacity of approximately 67,814.

Prediction favors the Indianapolis Colts with a point spread of -3 and moneyline odds of around -166, indicating a close game but with the Colts expected to cover the spread. The total points line is set at 48.5, with an over/under consensus leaning towards the over, reflecting expectations of a competitive and high-scoring match.

In their recent head-to-head matchups, the Indianapolis Colts have a slight edge with 6 wins out of the last 10 meetings against the Jacksonville Jaguars, who have won 3 times with 1 draw. The Colts have shown stronger performance in away games, while the Jaguars have been solid at home.