Houston Texans are favored due to a stronger 2025 finish and playoff positioning, with typical moneyline favorites around -140 to -160 against the Indianapolis Colts who are underdogs around +120 to +140; these ranges reflect Texans’ 10–5 form versus the Colts’ 8–7 slump and recent head-to-head momentum (odds vary by book). DexWin - Best Odds on Your Favourite Sports

The game starts on 1/4/2026 at 6:00:00 PM local time for the listed kickoff; that corresponds to 6:00 PM ET at Lucas Oil Stadium in Indianapolis (convert to your timezone as needed).

The match will be played at Lucas Oil Stadium in Indianapolis, Indiana — a domed stadium with a seating capacity around 67,000, a retractable roof-style design enabling controlled indoor conditions, and modern turf and broadcast facilities favored for NFL games.

Prediction: Houston Texans to win with a moneyline around -150 and an expected scoreline near 24–17 based on Texans’ stronger late-season offense and Colts’ offensive drop-off; implied win probability ~60% with Texans favored against Colts’ ~40% chance (betting lines fluctuate, stake accordingly).

In recent meetings the Texans hold the edge: across the last 10 competitive matchups Houston has won more games than Indianapolis, with several recent decisive wins contributing to Houston’s confidence; overall head-to-head favors the Texans though exact all-time totals vary by source.