Bet on Buffalo Bills vs Pittsburgh Steelers on American Football

Buffalo Bills are favored to win with moneyline odds around -186, while Pittsburgh Steelers are listed at approximately +148. The Bills have a stronger record this season and are performing better offensively and defensively compared to the Steelers.

The match starts at 4:25 PM EST on November 30, 2025, which is 9:25 PM UTC.

The game will be played at Acrisure Stadium in Pittsburgh, Pennsylvania, which has a seating capacity of approximately 68,400 and is known for its challenging environment for visiting teams.

Buffalo Bills are predicted to win by a margin of 3.5 to 4.5 points, with the over/under set at 46.5 to 47.5 points. The Bills' recent form, higher scoring average, and better defensive stats support this prediction.

In their last 10 meetings, Buffalo Bills hold a slight edge with 6 wins compared to Pittsburgh Steelers' 4 wins. The average total points scored in these matchups is 45.8, with the Bills averaging 24.2 points per game and the Steelers averaging 21.6 points per game.