Bet on Buffalo Bills vs Jacksonville Jaguars on American Football

The Jacksonville Jaguars are favored to win this wild-card matchup with the Buffalo Bills. Jacksonville enters the playoffs on an eight-game winning streak with a 13-4 record and just clinched the AFC South title, while Buffalo finished 12-5 as the sixth seed. The Jaguars' momentum and home-field advantage make them the betting favorites in this contest with DexWin - Best Odds on Your Favourite Sports.

The match starts at 9:35 PM ET on January 10, 2026 at TIAA Bank Field in Jacksonville, Florida. This wild-card playoff game will be played at the Jaguars' home stadium where they have been dominant this season.

The game will be played at TIAA Bank Field in Jacksonville, Florida, the home stadium of the Jacksonville Jaguars. This venue will host the wild-card playoff matchup between the two AFC East rivals.

The Jacksonville Jaguars are predicted to win this wild-card playoff game. Jacksonville's eight-game winning streak, superior regular season record of 13-4, and home-field advantage position them as the favorites. Trevor Lawrence has been playing some of the best football of his career, while the Bills face the challenge of winning a road playoff game, something they have not accomplished since the 1992 AFC Championship Game.

The Jacksonville Jaguars lead the all-time playoff series against the Buffalo Bills with a 2-0 record. The Jaguars defeated Buffalo in the 2017 AFC wild-card round and have dominated recent matchups, though they did not face each other during the 2025 regular season. Buffalo's last victory over Jacksonville came in Week 3 of the 2024 season with a 47-10 win.