Bet on Buffalo Bills vs Houston Texans on American Football

Buffalo Bills are favored to win with a 62.5% implied probability based on recent odds analysis. The Bills' stronger recent performance and superior overall team stats contribute to their favored status, although specific betting odds for the exact match time are not currently available.

The match is scheduled to start at 1:15 AM UTC on November 21, 2025, which corresponds to 8:15 PM EST on November 20, 2025.

The game will be played at NRG Stadium in Houston, Texas, which is the home stadium of the Houston Texans. NRG Stadium has a seating capacity of approximately 72,220 and features a retractable roof.

Predictions lean towards a Buffalo Bills victory considering their recent form and a 62.5% chance to win according to betting trends. Moneyline odds from recent sportsbooks suggest the Bills have a slight edge, but the Texans covering the spread remains a possibility given their home advantage.

In their last 10 head-to-head meetings, the Buffalo Bills have a winning record against the Houston Texans, with the Bills winning the majority of these encounters. The teams have shown competitive games, but Buffalo has generally maintained dominance in recent seasons.