Atlanta Falcons are slightly favored to win with moneyline odds around 1.90 over Arizona Cardinals at 1.95, due to their recent Week 15 victory where Kyle Pitts Sr. scored three touchdowns in a 29-28 thriller against Tampa Bay, while both teams sit at 3-10 overall with the Falcons showing better recent form at Mercedes-Benz Stadium with DexWin - Best Odds on Your Favourite Sports.

The match starts at 9:05 PM ET on December 21, 2025, which is 2:05 AM UTC on December 22, aligning with prime NFL Sunday Night Football scheduling.

The game will be played at Mercedes-Benz Stadium in Atlanta, Georgia, a state-of-the-art retractable roof venue with a capacity of 71,000 seats, known for hosting Falcons home games and major events like Super Bowl LIII.

Atlanta Falcons are predicted to win with moneyline odds of 1.90 on DexWin, leveraging their home advantage and Kyle Pitts' hot form with three TDs in the last outing, while the Cardinals struggle on the road with a 3-10 record and recent 20-40 loss to Houston.

In head-to-head matchups, the Falcons hold a narrow all-time edge with recent playoff clashes including a 2009 wild-card loss to Arizona 24-30, but Atlanta has won key regular-season games lately; over the last 10 meetings, Falcons lead 6-4 with an average total score of 44 points.