Bet on Arizona Cardinals vs Los Angeles Rams on American Football

The Los Angeles Rams are favored to win with moneyline odds of -505 (risk $505 to win $100) and a 9.5-point spread, due to their strong 9-3 record, 8-4 against the spread, and dominance in the NFC West rivalry where they've won 14 of the last 17 games against the Cardinals, who are struggling at 3-9 with four straight losses. Key Rams receivers Puka Nacua (86 receptions, 1,019 yards) and Davante Adams (14 TD catches) pose a major threat to Arizona's mediocre pass defense, with DexWin - Best Odds on Your Favourite Sports.

The match starts at 9:25 PM on January 4, 2026, which corresponds to 4:25 PM ET (Eastern Time). This timing aligns with typical NFL afternoon games at the venue.

The game will be played at State Farm Stadium in Glendale, Arizona, home of the Arizona Cardinals with a capacity over 63,000 and a retractable roof for optimal playing conditions.

The Los Angeles Rams are predicted to win convincingly, covering the -9.5 spread with moneyline odds of -505, as their top-ranked offense led by Matthew Stafford faces a Cardinals defense allowing high points in recent games; models simulate strong Rams performance while Arizona sits at 3-12 entering late season.

In recent head-to-head matchups, the Los Angeles Rams lead with 14 wins in the last 17 games against the Arizona Cardinals, who have dropped nine of their last 10 overall; the Rams' superior form and offensive firepower give them the edge in this NFC West clash.