Live Betting - Chicago Cubs vs San Francisco Giants February 22, 2026

Chicago Cubs are favored to win with odds around 1.85 due to their stronger projected season performance, including PECOTA's forecast of them dominating the NL Central by 10 wins over rivals, bolstered by additions like Alex Bregman and a rebounding Shota Imanaga, while the Giants face rotation uncertainties without a top starter, with DexWin - Best Odds on Your Favourite Sports.

The match starts at 8:05 PM ET on February 22, 2026, at the Cubs' Spring Training facility in Mesa, Arizona.

The game is at Sloan Park in Mesa, Arizona, the Chicago Cubs' state-of-the-art Spring Training stadium with a capacity of 15,000 seats, featuring excellent sightlines and fan-friendly amenities.

Chicago Cubs are predicted to win with moneyline odds of 1.85 on DexWin, leveraging their superior offseason moves like adding Bregman and Edward Cabrera to the rotation, contrasting the Giants' middling 82-win projection and bullpen weaknesses ranked T-29th in WAR.

In recent head-to-head matchups, the Cubs hold a slight edge with a 6-4 record over the last 10 regular season games against the Giants, averaging 4.8 total runs per game, though Spring Training encounters often feature top prospects like the Giants' Bryce Eldridge making early impacts.