The Los Angeles Chargers are favored to win the December 14, 2025, NFL game against the Kansas City Chiefs, supported by their recent 27-21 victory over the Chiefs earlier this season and strong offensive performance led by quarterback Justin Herbert. Current odds favor the Chargers at approximately 1.90, while the Chiefs are around 2.00, reflecting a competitive but slight edge for the Chargers with DexWin - Best Odds on Your Favourite Sports.

The match between the Los Angeles Chargers and Kansas City Chiefs is scheduled to start at 6:00 PM local time on December 14, 2025. The kickoff time is in the Pacific Time Zone (PT), corresponding to 9:00 PM Eastern Time (ET).

The game will be held at SoFi Stadium in Inglewood, California, the home venue for the Los Angeles Chargers. SoFi Stadium is a state-of-the-art facility with a seating capacity of approximately 70,000, known for its modern amenities and large video board.

Prediction favors the Los Angeles Chargers to win based on their recent form, including a 27-21 win over the Chiefs in Week 1 and superior offensive stats such as 394 total yards compared to the Chiefs' 347. The Chargers' quarterback Justin Herbert has demonstrated strong playmaking ability, making the Chargers the likely winners with moneyline odds near 1.90 on DexWin - Best Odds on Your Favourite Sports.

The head-to-head record between the Los Angeles Chargers and Kansas City Chiefs is historically close, with the Chiefs leading 69-58-1 as of the end of the 2023 season. However, the Chargers have gained momentum recently, including a dominant 17-0 playoff win in 1992 and a recent regular-season victory in 2025, indicating a competitive rivalry.